"assessment of lymphocyte subgroups in chronic brucellosis before and after immunotherapy"
نویسندگان
چکیده
brucellosis is an infectious disease and it seems that it affects human immune system and can cause acute, subacute and chronic clinical features. forty patients suffering from chronic brucellosis were studied for cd3+, cd4+,cd8+, cd19+, cells and cd4+/cd8+ ratio by flow cytometry before and after treatment with antibiotics and immunopotentiators. the results were compared with 15 healthy controls. the patients were divided into three groups: 1) antibiotic, 2) levomisol + antibiotic, and 3)treated with cimetidine + antibiotic. the results showed a significant decrease of b cells (cd19+), cd4+ t cells and cd4+/cd8+ ratio in comparison with normal subjects before treatment. in the first group, significant decrease of cd4 t cells and cd4/cd8 ratio inversion were seen after immunotherapy. the 3rd group showed the best correction of phenotype quantity. in other words, significant increase of cd4+ t cells, cd19+ b cells, cd4+/cd8+ratio and decrease of cd8+ t cells were seen with cimetidine immunotherapy.
منابع مشابه
ALTERATION OF T-LYMPHOCYTE SUBPOPULATIONS IN SUBACUTE AND CHRONIC BRUCELLOSIS
Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations...
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alteration of t-lymphocyte subpopulations in subacute and chronic brucellosis
human brucellosis is a major health problem in developing countries. a number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. since the pathophysiology of this change is not well understood, we studied the t-cell subsets during the acute, subacute and chronic forms of human brucellosis. in this study we found alterations in t...
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متن کامل
Chronic Brucellosis
disease. That it should be so rare in India is surprising considering that Polding (1947) reported that 10 per cent to 50 per cent of aborting Indian cattle in certain rural areas were infected with brucellosis and so long as we have brucellosis among cattle we will have the disease among human beings. The fact however is that even 85 per cent of cases of acute brucellosis are missed, being tak...
متن کاملSymptomatology of chronic brucellosis.
McDevitt, D. G. (1973). British Journal of Industrial Medicine, 30, 385-389. Symptomatology of chronic brucellosis. A survey of the occurrence of symptoms commonly attributed to chronic brucellosis was carried out by questionnaire in four different occupational groups in Northern Ireland-veterinary surgeons woiking in private practice, veterinary surgeons employed by the Ministry of Agriculture...
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عنوان ژورنال:
acta medica iranicaجلد ۴۲، شماره ۲، صفحات ۹۷-۱۰۰
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